The dengue virus (DENV) capsid protein is primarily involved in packaging the viral genome, but its role extends beyond viral assembly. While mainly localized to the endoplasmic reticulum and lipid droplets, it also shuttles between the cytoplasm and nucleus, guided by specific nuclear localization signals. This dynamic movement hints at potential interactions with host cellular machinery, suggesting broader implications in viral replication and pathogenesis. Understanding these mechanisms could provide deeper insights into DENV biology and its interplay with the host.