Characterization of host regulators of Dengue virus infection in the mosquito host
RNA viruses interact with multiple host RNA binding proteins to establish successful infection. This study focuses on identifying novel Dengue RNA-mosquito protein complexes that impact the viral life cycle using RNA-centric mass-spectrometry.
Studying the changes in the ER membrane proteomics upon dengue virus infection
Dengue virus infection remodels the ER membranes to form viral replication organelles. We are exploring changes in ER protein profiles upon DENV infection using quantitative proteomics to study how it impacts VRO formation and viral replication.
Developing Subgenomic Replicon systems of flaviviruses for antiviral screening
Sub-genomic replicons are great tools to study flaviviral replication without handling infectious virus. They allow for high throughput screening of antivirals that target viral replication, supporting drug discovery while reducing biosafety risks.
The Multifaceted Journey of DENV Capsid
The DENV capsid shuttles between the cytoplasm and the nucleus, hinting at roles beyond cytoplasmic genome packaging. Its localization to the nucleolus is surprising and we are currently exploring the impact of nucleolar capsid on viral pathogenesis.