During dengue virus infection, the endoplasmic reticulum undergoes significant structural and functional modifications to support viral replication. By studying changes in ER membrane proteomics, we can identify host proteins that are relocalized and may play essential roles in replication organelle formation. These insights help unravel the intricate virus-host interactions that facilitate infection, potentially revealing new targets for antiviral strategies. Understanding how the virus hijacks cellular machinery can contribute to the development of therapeutic interventions aimed at disrupting the replication process.

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